Correlations between microbiota and metabolites after faecal microbiota transfer in irritable bowel syndrome

Faecal microbiota transfer (FMT) consists of the infusion donor faecal material into intestine a patient with aim to restore disturbed gut microbiota. In this study, it was investigated whether FMT has an effect on microbial composition, its functional capacity, metabolite profiles and their interactions in 16 irritable bowel syndrome (IBS) patients. samples from eight different time points before until six months after allogenic (faecal healthy donor) as well autologous (own material) were analysed by 16S RNA gene amplicon sequencing gas chromatography coupled mass spectrometry (GS-MS). The results showed that resulted alterations composition detectable up months, whereas not case. Similar found for profiles, which predicted phylogenetic data. While both did have metabolites measured correlations between microbe-metabolite seemed be disrupted compared FMT. This shows can lead altered IBS Further research should investigate if how affects efficacy treatments.